SPON2
Function
Cell adhesion protein that promotes adhesion and outgrowth of hippocampal embryonic neurons. Binds directly to bacteria and their components and functions as an opsonin for macrophage phagocytosis of bacteria. Essential in the initiation of the innate immune response and represents a unique pattern-recognition molecule in the ECM for microbial pathogens (By similarity). Binds bacterial lipopolysaccharide (LPS).
Tissue Specificity
Expressed in normal lung tissue but not in lung carcinoma cell lines.
Cellular localization
- Secreted
- Extracellular space
- Extracellular matrix
Alternative names
DIL1, UNQ435/PRO866, SPON2, Spondin-2, Differentially expressed in cancerous and non-cancerous lung cells 1, Mindin, DIL-1