SPSB2
Domain
The SOCS box domain mediates the interaction with the Elongin BC complex, an adapter module in different E3 ubiquitin ligase complexes (By similarity). Essential for its ability to link NOS2 and the ECS E3 ubiquitin ligase complex components ELOC and CUL5.
Function
Substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:15601820, PubMed:21199876). Negatively regulates nitric oxide (NO) production and limits cellular toxicity in activated macrophages by mediating the ubiquitination and proteasomal degradation of NOS2 (PubMed:21199876). Acts as a bridge which links NOS2 with the ECS E3 ubiquitin ligase complex components ELOC and CUL5 (PubMed:21199876).
Pathway
Protein modification; protein ubiquitination.
Sequence Similarities
Belongs to the SPSB family.
Cellular localization
- Cytoplasm
- Cytoplasm
- Cytosol
- Exhibits a diffuse cytosolic localization.
Alternative names
GRCC9, SSB2, SPSB2, SPRY domain-containing SOCS box protein 2, SSB-2, Gene-rich cluster protein C9