Sptan1
Developmental stage
Expressed throughout glomerulogenesis.
Function
Fodrin, which seems to be involved in secretion, interacts with calmodulin in a calcium-dependent manner and is thus candidate for the calcium-dependent movement of the cytoskeleton at the membrane.
Post-translational modifications
Phosphorylation of Tyr-1176 decreases sensitivity to cleavage by calpain in vitro.
Sequence Similarities
Belongs to the spectrin family.
Tissue Specificity
Expressed in the foot process layer of podocytes in the kidney glomerulus and in tubules (at protein level).
Cellular localization
- Cytoplasm
- Cytoskeleton
- Cytoplasm
- Cell cortex
- Expressed along the cell membrane in podocytes and presumptive tubule cells during glomerulogenesis and is expressed along lateral cell margins in tubule cells.
Alternative names
Spna2, Spta2, Alpha-II spectrin, Fodrin alpha chain