SRGAP1
Domain
The F-BAR domain mediates oligomerization, binds membranes, and constrains plasma membrane protrusions.
Function
GTPase-activating protein for RhoA and Cdc42 small GTPases. Together with CDC42 seems to be involved in the pathway mediating the repulsive signaling of Robo and Slit proteins in neuronal migration. SLIT2, probably through interaction with ROBO1, increases the interaction of SRGAP1 with ROBO1 and inactivates CDC42.
Involvement in disease
Thyroid cancer, non-medullary, 2
NMTC2
A form of non-medullary thyroid cancer (NMTC), a cancer characterized by tumors originating from the thyroid follicular cells. NMTCs represent approximately 95% of all cases of thyroid cancer and are classified into papillary, follicular, Hurthle cell, and anaplastic neoplasms.
None
Disease susceptibility is associated with variants affecting the gene represented in this entry.
Tissue Specificity
Expressed in brain, lung, kidney, and testis.
Alternative names
ARHGAP13, KIAA1304, SRGAP1, SLIT-ROBO Rho GTPase-activating protein 1, srGAP1, Rho GTPase-activating protein 13