SRMS
Domain
The N-terminal region regulates its kinase activity.
Function
Non-receptor tyrosine-protein kinase which phosphorylates DOK1 on tyrosine residues (PubMed:23822091). Also phosphorylates KHDRBS1/SAM68 and VIM on tyrosine residues (PubMed:29496907). Phosphorylation of KHDRBS1 is EGF-dependent (PubMed:29496907). Phosphorylates OTUB1, promoting deubiquitination of RPTOR (PubMed:35927303).
Sequence Similarities
Belongs to the protein kinase superfamily. Tyr protein kinase family. SRC subfamily.
Tissue Specificity
Highly expressed in most breast cancers (at protein level).
Cellular localization
- Cytoplasm
- Localizes to punctate cytoplasmic structures.
Alternative names
C20orf148, SRMS, Tyrosine-protein kinase Srms