SRMS

The N-terminal region regulates its kinase activity.

Non-receptor tyrosine-protein kinase which phosphorylates DOK1 on tyrosine residues (PubMed:23822091). Also phosphorylates KHDRBS1/SAM68 and VIM on tyrosine residues (PubMed:29496907). Phosphorylation of KHDRBS1 is EGF-dependent (PubMed:29496907). Phosphorylates OTUB1, promoting deubiquitination of RPTOR (PubMed:35927303).

Belongs to the protein kinase superfamily. Tyr protein kinase family. SRC subfamily.

Highly expressed in most breast cancers (at protein level).

• Cytoplasm
• Localizes to punctate cytoplasmic structures.

C20orf148, SRMS, Tyrosine-protein kinase Srms

• entrezGene:6725
• swissprot:Q9H3Y6

Proteins

Oncology

54507Da