SRSF10

Function

Splicing factor that in its dephosphorylated form acts as a general repressor of pre-mRNA splicing (PubMed:11684676, PubMed:12419250, PubMed:14765198). Seems to interfere with the U1 snRNP 5'-splice recognition of SNRNP70 (PubMed:14765198). Required for splicing repression in M-phase cells and after heat shock (PubMed:14765198). Also acts as a splicing factor that specifically promotes exon skipping during alternative splicing (PubMed:26876937). Interaction with YTHDC1, a RNA-binding protein that recognizes and binds N6-methyladenosine (m6A)-containing RNAs, prevents SRSF10 from binding to its mRNA-binding sites close to m6A-containing regions, leading to inhibit exon skipping during alternative splicing (PubMed:26876937). May be involved in regulation of alternative splicing in neurons, with isoform 1 acting as a positive and isoform 3 as a negative regulator (PubMed:12419250).

Post-translational modifications

Phosphorylated. Fully dephosphorylated in mitosis and partially dephosphorylated on heat shock.

Sequence Similarities

Belongs to the splicing factor SR family.

Tissue Specificity

Widely expressed.

Cellular localization

• Nucleus speckle
• Cytoplasm

Alternative names

FUSIP1, FUSIP2, SFRS13A, TASR, SRSF10, Serine/arginine-rich splicing factor 10, 40 kDa SR-repressor protein, FUS-interacting serine-arginine-rich protein 1, Splicing factor SRp38, TLS-associated protein with Ser-Arg repeats, TLS-associated serine-arginine protein, SRrp40, TLS-associated protein with SR repeats, TLS-associated SR protein

Database links

swissprot:O75494 omim:605221 entrezGene:100505793 entrezGene:10772