SRSF7
Function
Required for pre-mRNA splicing. Can also modulate alternative splicing in vitro. Represses the splicing of MAPT/Tau exon 10. May function as export adapter involved in mRNA nuclear export such as of histone H2A. Binds mRNA which is thought to be transferred to the NXF1-NXT1 heterodimer for export (TAP/NXF1 pathway); enhances NXF1-NXT1 RNA-binding activity. RNA-binding is semi-sequence specific.
Post-translational modifications
Extensively phosphorylated on serine residues in the RS domain.
Sequence Similarities
Belongs to the splicing factor SR family.
Tissue Specificity
Brain, liver, kidney and lung.
Cellular localization
- Nucleus
- Cytoplasm
Alternative names
SFRS7, SRSF7, Serine/arginine-rich splicing factor 7, Splicing factor 9G8