Contributes to oxidative stress resistance by reducing cysteine-sulfinic acid formed under exposure to oxidants in the peroxiredoxins PRDX1, PRDX2, PRDX3 and PRDX4 (PubMed:15448164, PubMed:15590625). Does not act on PRDX5 or PRDX6 (PubMed:15448164, PubMed:15590625). May catalyze the reduction in a multi-step process by acting both as a specific phosphotransferase and a thioltransferase (PubMed:15448164, PubMed:15590625).
Belongs to the sulfiredoxin family.
Widely expressed with highest levels in kidney, lung, spleen and thymus.
C20orf139, SRX, SRX1, SRXN1, Sulfiredoxin-1
Proteins
Neuroscience
14259Da
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