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SSB

Function

Binds to the 3' poly(U) terminus of nascent RNA polymerase III transcripts, protecting them from exonuclease digestion and facilitating their folding and maturation (PubMed:3192525, PubMed:2470590). In case of Coxsackievirus B3 infection, binds to the viral internal ribosome entry site (IRES) and stimulates the IRES-mediated translation (PubMed:12384597).

Post-translational modifications

Phosphorylated. The phosphorylation sites are at the C-terminal part of the protein.

The N-terminus is blocked.

Cellular localization

  • Nucleus

Alternative names

  • Lupus La protein
  • La autoantigen
  • La ribonucleoprotein
  • Sjoegren syndrome type B antigen
  • SS-B
  • SSB

Target type

Proteins

Molecular weight

46837Da