SSH2
Function
Protein phosphatase which regulates actin filament dynamics. Dephosphorylates and activates the actin binding/depolymerizing factor cofilin, which subsequently binds to actin filaments and stimulates their disassembly. Inhibitory phosphorylation of cofilin is mediated by LIMK1, which may also be dephosphorylated and inactivated by this protein (PubMed:11832213). Required for spermatogenesis (By similarity). Involved in acrosome biogenesis, probably by regulating cofilin-mediated actin cytoskeleton remodeling during proacrosomal vesicle fusion and/or Golgi to perinuclear vesicle trafficking (By similarity).
Sequence Similarities
Belongs to the protein-tyrosine phosphatase family.
Cellular localization
- Cytoplasm
- Cytoplasm
- Cytoskeleton
- Cell junction
- Focal adhesion
- Cytoplasmic vesicle
- Secretory vesicle
- Acrosome
- Colocalizes with filamentous actin in the cytoplasm and the cell periphery.
Alternative names
KIAA1725, SSH2L, SSH2, Protein phosphatase Slingshot homolog 2, SSH-like protein 2, SSH-2L, hSSH-2L