SSPN
Function
Component of the dystrophin-glycoprotein complex (DGC), a complex that spans the muscle plasma membrane and forms a link between the F-actin cytoskeleton and the extracellular matrix. Preferentially associates with the sarcoglycan subcomplex of the DGC.
Tissue Specificity
Isoform 1 is expressed exclusively in heart and skeletal muscle. Isoform 2 is expressed in heart, skeletal muscle, thymus, prostate, testis, ovary, small intestine, colon and spleen.
Cellular localization
- Cell membrane
- Multi-pass membrane protein
- Cell membrane
- Sarcolemma
- Postsynaptic cell membrane
- Multi-pass membrane protein
- Also found in myotendinous junctions and in the postsynaptic membrane of neuromuscular junctions.
Alternative names
KRAG, SSPN, Sarcospan, K-ras oncogene-associated protein, Kirsten-ras-associated protein