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SSTR1

Function

Receptor for somatostatin with higher affinity for somatostatin-14 than -28. This receptor is coupled via pertussis toxin sensitive G proteins to inhibition of adenylyl cyclase. In addition it stimulates phosphotyrosine phosphatase and Na(+)/H(+) exchanger via pertussis toxin insensitive G proteins.

Sequence Similarities

Belongs to the G-protein coupled receptor 1 family.

Tissue Specificity

Fetal kidney, fetal liver, and adult pancreas, brain, lung, jejunum and stomach.

Cellular localization

Alternative names

Somatostatin receptor type 1, SS-1-R, SS1-R, SS1R, SST1, SRIF-2, SSTR1

swissprot:P30872 omim:182451 entrezGene:6751