ST6GAL1
Function
Transfers sialic acid from CMP-sialic acid to galactose-containing acceptor substrates.
Pathway
Protein modification; protein glycosylation.
Post-translational modifications
The soluble form derives from the membrane form by proteolytic processing.
The HB-6, CDW75, and CD76 differentiation antigens are cell-surface carbohydrate determinants generated by this enzyme.
N-glycosylated.
Sequence Similarities
Belongs to the glycosyltransferase 29 family.
Cellular localization
- Golgi apparatus
- Golgi stack membrane
- Single-pass type II membrane protein
- Secreted
- Membrane-bound form in trans cisternae of Golgi. Secreted into the body fluid.
Alternative names
SIAT1, ST6GAL1, B-cell antigen CD75, ST6Gal I, Sialyltransferase 1, ST6GalI