ST6GAL2
Function
Transfers sialic acid from the donor of substrate CMP-sialic acid to galactose containing acceptor substrates. Has alpha-2,6-sialyltransferase activity toward oligosaccharides that have the Gal-beta-1,4-GlcNAc sequence at the non-reducing end of their carbohydrate groups, but it has weak or no activities toward glycoproteins and glycolipids.
Post-translational modifications
O-glycosylated.
Sequence Similarities
Belongs to the glycosyltransferase 29 family.
Tissue Specificity
Weakly expressed in some tissues, such as small intestine, colon and fetal brain.
Cellular localization
- Golgi apparatus
- Golgi stack membrane
- Single-pass type II membrane protein
Alternative names
KIAA1877, SIAT2, ST6GAL2, ST6Gal II, Sialyltransferase 2, ST6GalII, hST6Gal II