STAB2
Domain
Recognizes phosphatidyl serine via its epidermal growth factor-like domains.
Function
Phosphatidylserine receptor that enhances the engulfment of apoptotic cells. Hyaluronan receptor that binds to and mediates endocytosis of hyaluronic acid (HA). Acts also, in different species, as a primary systemic scavenger receptor for heparin (Hep), chondroitin sulfate (CS), dermatan sulfate (DS), nonglycosaminoglycan (GAG), acetylated low-density lipoprotein (AcLDL), pro-collagen propeptides and advanced glycation end products (AGE). May serve to maintain tissue integrity by supporting extracellular matrix turnover or it may contribute to maintaining fluidity of bodily liquids by resorption of hyaluronan. Counter receptor which plays an important role in lymphocyte recruitment in the hepatic vasculature. Binds to both Gram-positive and Gram-negative bacteria and may play a role in defense against bacterial infection. The proteolytically processed 190 kDa form also functions as an endocytosis receptor for heparin internalization as well as HA and CS.
Post-translational modifications
Glycosylated.
Proteolytically processed to yield a 190 kDa protein.
Tissue Specificity
Highly expressed in sinusoidal endothelial cells of liver, spleen and lymph nodes. Also expressed in non SEC-cells such as HMDMs (monocyte-derivedmacrophages), HAMs (T-cell leukemia virus type 1-associated myelopathy), and several macrophage cell line.
Cellular localization
- Cell membrane
- Single-pass type I membrane protein
- Cytoplasm
- Only a small amount appears to be present at the cell surface (PubMed:17145755).
Alternative names
FEEL2, FELL, FEX2, HARE, STAB2, Stabilin-2, FAS1 EGF-like and X-link domain-containing adhesion molecule 2, Hyaluronan receptor for endocytosis, FEEL-2