STAM
Domain
The VHS domain mediates high-avidity binding to Lys63-linked and Lys48-linked polyubiquitinated cargos.
Function
Involved in intracellular signal transduction mediated by cytokines and growth factors. Upon IL-2 and GM-CSL stimulation, it plays a role in signaling leading to DNA synthesis and MYC induction. May also play a role in T-cell development. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with HGS (ESCRT-0 complex). The ESCRT-0 complex binds ubiquitin and acts as a sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes.
(Microbial infection) Plays an important role in Dengue virus entry.
Post-translational modifications
Phosphorylated on Tyr-198. Phosphorylated in response to IL2, IL3, IL4, IL7, CSF2/GM-CSF, EGF and PDGFB. Phosphorylated by activated PDGFRB.
Ubiquitinated by ITCH.
Sequence Similarities
Belongs to the STAM family.
Tissue Specificity
Ubiquitously expressed.
Cellular localization
- Cytoplasm
- Early endosome membrane
- Peripheral membrane protein
- Cytoplasmic side
Alternative names
STAM1, STAM, Signal transducing adapter molecule 1, STAM-1