STAM

Domain

The VHS domain mediates high-avidity binding to Lys63-linked and Lys48-linked polyubiquitinated cargos.

Function

Involved in intracellular signal transduction mediated by cytokines and growth factors. Upon IL-2 and GM-CSL stimulation, it plays a role in signaling leading to DNA synthesis and MYC induction. May also play a role in T-cell development. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with HGS (ESCRT-0 complex). The ESCRT-0 complex binds ubiquitin and acts as sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes.

Post-translational modifications

Phosphorylated on Tyr-198. Phosphorylated in response to IL2, IL3, IL4, IL7, CSF2/GM-CSF, EGF and PDGFB. Phosphorylated by activated PDGFRB.

Ubiquitinated by ITCH.

Sequence similarities

Belongs to the STAM family.

Tissue specificity

Ubiquitously expressed.

Cellular localization

• Cytoplasm
• Early endosome membrane
• Peripheral membrane protein
• Cytoplasmic side

Alternative names

• Signal transducing adapter molecule 1
• STAM-1
• STAM1
• STAM

Database links

• entrezGene:8027
• omim:601899
• swissprot:Q92783

Target type

Proteins

Primary research area

Neuroscience

Molecular weight

59180Da