Stam2
Domain
The VHS and UIM domains mediate the interaction with ubiquitinated proteins.
The SH3 domain mediates the interaction with USP8.
Contains one Pro-Xaa-Val-Xaa-Leu (PxVxL) motif, which is required for interaction with chromoshadow domains. This motif requires additional residues -7, -6, +4 and +5 of the central Val which contact the chromoshadow domain.
Function
Involved in intracellular signal transduction mediated by cytokines and growth factors. Upon IL-2 and GM-CSL stimulation, it plays a role in signaling leading to DNA synthesis and MYC induction. May also play a role in T-cell development. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with HGS (ESCRT-0 complex). The ESCRT-0 complex binds ubiquitin and acts as a sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes (By similarity).
Post-translational modifications
Phosphorylated in response to IL-2, GM-CSF, EGF and PDGF.
Sequence Similarities
Belongs to the STAM family.
Tissue Specificity
Ubiquitously expressed, with highest levels in testis.
Cellular localization
- Cytoplasm
- Early endosome membrane
- Peripheral membrane protein
- Cytoplasmic side
Alternative names
Hbp, Stam2, Signal transducing adapter molecule 2, STAM-2, Hrs-binding protein