STAMBPL1
Domain
The JAMM motif is essential for the protease activity.
Function
Zinc metalloprotease that specifically cleaves 'Lys-63'-linked polyubiquitin chains (PubMed:18758443, PubMed:35114100). Acts as a positive regulator of the TORC1 signaling pathway by mediating 'Lys-63'-linked deubiquitination of SESN2, thereby inhibiting SESN2-interaction with the GATOR2 complex (PubMed:35114100). Does not cleave 'Lys-48'-linked polyubiquitin chains (PubMed:18758443).
Sequence Similarities
Belongs to the peptidase M67C family.
Tissue Specificity
Ubiquitously expressed.
Alternative names
AMSHLP, KIAA1373, STAMBPL1, AMSH-like protease, AMSH-LP, STAM-binding protein-like 1