STARD10
Function
May play metabolic roles in sperm maturation or fertilization (By similarity). Phospholipid transfer protein that preferentially selects lipid species containing a palmitoyl or stearoyl chain on the sn-1 and an unsaturated fatty acyl chain (18:1 or 18:2) on the sn-2 position. Able to transfer phosphatidylcholine (PC) and phosphatidyetanolamline (PE) between membranes.
Post-translational modifications
Phosphorylation at Ser-284 by CK2 negatively regulates lipid transfer activity, possibly by decreasing membrane association.
Cellular localization
- Cell projection
- Cilium
- Flagellum
- Cytoplasm
- Membrane
- In testis was predominantly detected at the flagella of elongated spermatids, with a strong signal also found at the tail of epididymal sperm (By similarity). Mainly cytosolic.
Alternative names
SDCCAG28, CGI-52, STARD10, START domain-containing protein 10, StARD10, Antigen NY-CO-28, PCTP-like protein, Serologically defined colon cancer antigen 28, StAR-related lipid transfer protein 10, PCTP-L