STARD3NL
Domain
The FFAT motif mediates interaction with VAPA, VAPB and MOSPD2.
The MENTAL domain anchors the protein in endosome membranes and exposes the START domain in the cytosol (By similarity). It binds cholesterol and mediates homotypic as well as heterotypic interactions between STARD3 and STARD3NL (PubMed:15718238, PubMed:16709157).
Function
Tethering protein that creates contact site between the endoplasmic reticulum and late endosomes: localizes to late endosome membranes and contacts the endoplasmic reticulum via interaction with VAPA and VAPB (PubMed:24105263).
Sequence Similarities
Belongs to the STARD3 family.
Cellular localization
- Late endosome membrane
- Multi-pass membrane protein
- Localizes to contact sites between the endoplasmic reticulum and late endosomes: associates with the endoplasmic reticulum membrane via interaction with VAPA, VAPB or MOSPD2.
Alternative names
MENTHO, UNQ855/PRO1864, STARD3NL, STARD3 N-terminal-like protein, MLN64 N-terminal domain homolog