Stat6 phospho Y641
Function
Carries out a dual function: signal transduction and activation of transcription. Involved in IL4/interleukin-4- and IL3/interleukin-3-mediated signaling.
Post-translational modifications
Tyrosine phosphorylated on Tyr-641 following stimulation by IL4/interleukin-4. Tyrosine phosphorylated following stimulation by IL3/interleukin-3. Dephosphorylation on tyrosine residues by PTPN2 negatively regulates the IL4/interleukin-4 mediated signaling.
Mono-ADP-ribosylated by PARP14.
Sequence Similarities
Belongs to the transcription factor STAT family.
Cellular localization
- Cytoplasm
- Nucleus
- Translocated into the nucleus in response to phosphorylation.
Alternative names
Signal transducer and transcription activator 6, Stat6
Database links
Other research areas
- Immuno-oncology