STAT6 phospho Y641
Function
Carries out a dual function: signal transduction and activation of transcription. Involved in IL4/interleukin-4- and IL3/interleukin-3-mediated signaling.
Involvement in disease
Hyper-IgE syndrome 6, autosomal dominant, with recurrent infections
HIES6
An immunologic disorder characterized by severe allergic disease with onset in infancy. Common features are treatment-resistant atopic dermatitis, food allergies, asthma, eosinophilic gastrointestinal disease, and severe episodes of anaphylaxis. Half of the patients present with recurrent skin, respiratory, and viral infections. Clinical laboratory testing is notable for eosinophilia and markedly elevated serum IgE levels.
None
The disease is caused by variants affecting the gene represented in this entry.
Post-translational modifications
Tyrosine phosphorylated on Tyr-641 following stimulation by IL4/interleukin-4 (PubMed:27796300). Tyrosine phosphorylated following stimulation by IL3/interleukin-3 (By similarity). Dephosphorylation on tyrosine residues by PTPN2 negatively regulates the IL4/interleukin-4 mediated signaling (PubMed:17210636).
Mono-ADP-ribosylated by PARP14.
Sequence Similarities
Belongs to the transcription factor STAT family.
Cellular localization
- Cytoplasm
- Nucleus
- Translocated into the nucleus in response to phosphorylation.
Alternative names
Signal transducer and activator of transcription 6, IL-4 Stat, STAT6
Database links
Other research areas
- Immuno-oncology