STAT6
GeneName
STAT6
Summary
STAT6, also referred to as STAT-6, is a 94 kDa transcription factor that plays a pivotal role in mediating signal transduction for various cytokines, particularly those associated with the JAK-STAT pathway. It is predominantly localised in the nucleus and cytoplasm, where it functions as a DNA-binding transcription activator specific to RNA polymerase II. STAT6 is involved in several biological processes including interleukin-4-mediated signalling, which is crucial for the differentiation of T-helper 2 cells and isotype switching to IgE in B cells. Additionally, it has roles in mammary gland development and the regulation of immune responses, particularly in the context of allergic and inflammatory conditions.
Importance
STAT6 is relevant to: - The regulation of immune responses, particularly in allergy and asthma, through its role in interleukin-4 signalling and IgE production. - Understanding the mechanisms of T-helper cell differentiation, which has implications for autoimmune diseases and immunotherapy. - Investigating mammary gland biology, including development and cancer, due to its involvement in epithelial cell proliferation and morphogenesis. - Exploring therapeutic targets in conditions associated with dysregulated JAK-STAT signalling, such as certain cancers and chronic inflammatory diseases.
Top Products
For researchers investigating STAT6, we highly recommend the top-selling recombinant monoclonal antibody, Anti-STAT6 antibody [YE361] (ab32520). This antibody has been validated in knockout models, ensuring its reliability in various applications, including Western blotting (WB), immunohistochemistry (IHC), immunocytochemistry (ICC), flow cytometry (FC), and immunoprecipitation (IP). With 86 citations, it is well-regarded in the research community, making it an excellent choice for those seeking robust and consistent performance in their studies of STAT6.
Abcam Product Citation Summary
The data indicates that the STAT6 target is being investigated in the context of cancer and viral infections, particularly focusing on transcriptional regulation and protein stability. The use of human cell lines such as HEK293 and HeLa highlights the relevance of these studies in understanding the molecular mechanisms underlying these conditions.
Abcam Product Citation Table
Function
Carries out a dual function: signal transduction and activation of transcription. Involved in IL4/interleukin-4- and IL3/interleukin-3-mediated signaling.
Involvement in disease
Hyper-IgE syndrome 6, autosomal dominant, with recurrent infections
HIES6
An immunologic disorder characterized by severe allergic disease with onset in infancy. Common features are treatment-resistant atopic dermatitis, food allergies, asthma, eosinophilic gastrointestinal disease, and severe episodes of anaphylaxis. Half of the patients present with recurrent skin, respiratory, and viral infections. Clinical laboratory testing is notable for eosinophilia and markedly elevated serum IgE levels.
None
The disease is caused by variants affecting the gene represented in this entry.
Post-translational modifications
Tyrosine phosphorylated on Tyr-641 following stimulation by IL4/interleukin-4 (PubMed:27796300). Tyrosine phosphorylated following stimulation by IL3/interleukin-3 (By similarity). Dephosphorylation on tyrosine residues by PTPN2 negatively regulates the IL4/interleukin-4 mediated signaling (PubMed:17210636).
Mono-ADP-ribosylated by PARP14.
Sequence Similarities
Belongs to the transcription factor STAT family.
Cellular localization
- Cytoplasm
- Nucleus
- Translocated into the nucleus in response to phosphorylation.
Alternative names
Signal transducer and activator of transcription 6, IL-4 Stat, STAT6
Database links
swissprot:P42226 entrezGene:6778 omim:601512
Other research areas
- Immuno-oncology
- Immunology & Infectious Disease