STAT6

Carries out a dual function: signal transduction and activation of transcription. Involved in IL4/interleukin-4- and IL3/interleukin-3-mediated signaling.

Hyper-IgE syndrome 6, autosomal dominant, with recurrent infections

HIES6

An immunologic disorder characterized by severe allergic disease with onset in infancy. Common features are treatment-resistant atopic dermatitis, food allergies, asthma, eosinophilic gastrointestinal disease, and severe episodes of anaphylaxis. Half of the patients present with recurrent skin, respiratory, and viral infections. Clinical laboratory testing is notable for eosinophilia and markedly elevated serum IgE levels.

None

The disease is caused by variants affecting the gene represented in this entry.

Tyrosine phosphorylated on Tyr-641 following stimulation by IL4/interleukin-4 (PubMed:27796300). Tyrosine phosphorylated following stimulation by IL3/interleukin-3 (By similarity). Dephosphorylation on tyrosine residues by PTPN2 negatively regulates the IL4/interleukin-4 mediated signaling (PubMed:17210636).

Mono-ADP-ribosylated by PARP14.

Belongs to the transcription factor STAT family.

• Cytoplasm
• Nucleus
• Translocated into the nucleus in response to phosphorylation.

Signal transducer and activator of transcription 6, IL-4 Stat, STAT6

• entrezGene:6778
• omim:601512
• swissprot:P42226

Proteins

Immunology & Infectious Disease

• Immuno-oncology

94135Da