STAT6

Function

Carries out a dual function: signal transduction and activation of transcription. Involved in IL4/interleukin-4- and IL3/interleukin-3-mediated signaling.

Post-translational modifications

Tyrosine phosphorylated on Tyr-641 following stimulation by IL4/interleukin-4 (PubMed:27796300). Tyrosine phosphorylated following stimulation by IL3/interleukin-3 (By similarity). Dephosphorylation on tyrosine residues by PTPN2 negatively regulates the IL4/interleukin-4 mediated signaling (PubMed:17210636).

Mono-ADP-ribosylated by PARP14.

Sequence similarities

Belongs to the transcription factor STAT family.

Cellular localization

• Cytoplasm
• Nucleus
• Translocated into the nucleus in response to phosphorylation.

Alternative names

• Signal transducer and activator of transcription 6
• IL-4 Stat
• STAT6

Database links

• entrezGene:6778
• omim:601512
• swissprot:P42226

Target type

Proteins

Primary research area

Epigenetics

Other research areas

• Immuno-oncology
• Immunology & Infectious Disease

Molecular weight

94135Da