STAU1
Domain
One of the DRDB could be involved in RER binding.
The C-terminal contains the tubulin binding domain (TBD).
Function
Binds double-stranded RNA (regardless of the sequence) and tubulin. May play a role in specific positioning of mRNAs at given sites in the cell by cross-linking cytoskeletal and RNA components, and in stimulating their translation at the site.
(Microbial infection) Plays a role in virus particles production of many viruses including of HIV-1, HERV-K, ebola virus and influenza virus. Acts by interacting with various viral proteins involved in particle budding process.
Tissue Specificity
Widely expressed. Expressed in brain, pancreas, heart, skeletal muscles, liver, lung, kidney and placenta.
Cellular localization
- Cytoplasm
- Rough endoplasmic reticulum
- Localizes exclusively with the rough reticulum endoplasmic (RER).
Alternative names
STAU, STAU1, Double-stranded RNA-binding protein Staufen homolog 1