STBD1

The LIR motif (LC3-interacting region) is required for the interaction with the ATG8 family protein GABARAPL1.

The C-terminal CBM20 domain is required for the interaction with glycogen and glycogen-associated proteins.

Acts as a cargo receptor for glycogen. Delivers its cargo to an autophagic pathway called glycophagy, resulting in the transport of glycogen to lysosomes.

Ubiquitinated, which leads to proteasomal degradation.

Expressed at high level in skeletal and cardiac muscles. Moderately expressed in liver and placenta. No expression is found in pancreas, kidney or lung. Present in skeletal muscle, heart and placenta (at protein level).

• Preautophagosomal structure membrane
• Single-pass type III membrane protein
• Endoplasmic reticulum membrane
• Single-pass type III membrane protein
• Cell membrane
• Sarcolemma
• T-tubule
• Also detected near the junctional sarcoplasmic reticulum (PubMed:9794794). Concentrates at perinuclear structures (PubMed:21893048).

GENX-3414, STBD1, Starch-binding domain-containing protein 1, Genethonin-1, Glycophagy cargo receptor STBD1

• entrezGene:8987
• omim:607406
• swissprot:O95210

Proteins

Neuroscience

39007Da