STBD1
Domain
The LIR motif (LC3-interacting region) is required for the interaction with the ATG8 family protein GABARAPL1.
The C-terminal CBM20 domain is required for the interaction with glycogen and glycogen-associated proteins.
Function
Acts as a cargo receptor for glycogen. Delivers its cargo to an autophagic pathway called glycophagy, resulting in the transport of glycogen to lysosomes.
Post-translational modifications
Ubiquitinated, which leads to proteasomal degradation.
Tissue Specificity
Expressed at high level in skeletal and cardiac muscles. Moderately expressed in liver and placenta. No expression is found in pancreas, kidney or lung. Present in skeletal muscle, heart and placenta (at protein level).
Cellular localization
- Preautophagosomal structure membrane
- Single-pass type III membrane protein
- Endoplasmic reticulum membrane
- Single-pass type III membrane protein
- Cell membrane
- Sarcolemma
- T-tubule
- Also detected near the junctional sarcoplasmic reticulum (PubMed:9794794). Concentrates at perinuclear structures (PubMed:21893048).
Alternative names
GENX-3414, STBD1, Starch-binding domain-containing protein 1, Genethonin-1, Glycophagy cargo receptor STBD1