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Stanniocalcin 1/STC

Function

Stimulates renal phosphate reabsorption, and could therefore prevent hypercalcemia.

Sequence similarities

Belongs to the stanniocalcin family.

Tissue specificity

Expressed in most tissues, with the highest levels in ovary, prostate, heart, kidney and thyroid. In the kidney, expression is confined to the nephron, specifically in the distal convoluted tubule and in the collecting tubule. Not detected in the brain, liver, spleen, peripheral blood leukocytes and adrenal medulla.

Cellular localization

  • Secreted

Alternative names

  • Stanniocalcin-1
  • STC-1
  • STC
  • STC1

Target type

Proteins

Molecular weight

27621Da