STEAP1
Function
Does not function as a metalloreductase due to the absence of binding sites for the electron-donating substrate NADPH. Promotes Fe(3+) reduction when fused to the NADPH-binding domain of STEAP4.
Sequence Similarities
Belongs to the STEAP family.
Tissue Specificity
Ubiquitously expressed. Highly expressed in prostate tumors.
Cellular localization
- Endosome membrane
- Multi-pass membrane protein
- Cell membrane
- Multi-pass membrane protein
Alternative names
PRSS24, STEAP, STEAP1, STEAP1 protein, Six-transmembrane epithelial antigen of prostate 1