STEAP2
Function
Integral membrane protein that functions as a NADPH-dependent ferric-chelate reductase, using NADPH from one side of the membrane to reduce a Fe(3+) chelate that is bound on the other side of the membrane (By similarity). Mediates sequential transmembrane electron transfer from NADPH to FAD and onto heme, and finally to the Fe(3+) chelate (By similarity). Can also reduce Cu(2+) to Cu(1+) (By similarity).
Sequence Similarities
Belongs to the STEAP family.
Tissue Specificity
Expressed at high levels in prostate and at significantly lower levels in heart, brain, kidney, pancreas, and ovary.
Cellular localization
- Endosome membrane
- Multi-pass membrane protein
- Cell membrane
- Multi-pass membrane protein
Alternative names
PCANAP1, STAMP1, UNQ6507/PRO23203, STEAP2, Metalloreductase STEAP2, Prostate cancer-associated protein 1, Protein up-regulated in metastatic prostate cancer, Six-transmembrane epithelial antigen of prostate 2, SixTransMembrane protein of prostate 1, PUMPCn