STIM2

Plays a role in mediating store-operated Ca(2+) entry (SOCE), a Ca(2+) influx following depletion of intracellular Ca(2+) stores. Functions as a highly sensitive Ca(2+) sensor in the endoplasmic reticulum which activates both store-operated and store-independent Ca(2+)-influx. Regulates basal cytosolic and endoplasmic reticulum Ca(2+) concentrations. Upon mild variations of the endoplasmic reticulum Ca(2+) concentration, translocates from the endoplasmic reticulum to the plasma membrane where it probably activates the Ca(2+) release-activated Ca(2+) (CRAC) channels ORAI1, ORAI2 and ORAI3. May inhibit STIM1-mediated Ca(2+) influx.

Glycosylated.

Phosphorylated predominantly on Ser residues.

Expressed in all tissues and tumor cell lines examined.

• Endoplasmic reticulum membrane
• Single-pass type I membrane protein
• Dynamically translocates from a uniform endoplasmic reticulum distribution to punctual endoplasmic reticulum-plasma membrane junctions in response to decrease in endoplasmic reticulum Ca(2+) concentration.

KIAA1482, STIM2, Stromal interaction molecule 2

• entrezGene:57620
• omim:610841
• swissprot:Q9P246

Proteins

Neuroscience

83971Da