STK16

Membrane-associated protein kinase that phosphorylates on serine and threonine residues. In vitro substrates include DRG1, ENO1 and EIF4EBP1. Also autophosphorylates. May be involved in secretory vesicle trafficking or intracellular signaling. May have a role in regulating stromal-epithelial interactions that occur during ductal morphogenesis in the mammary gland. May be involved in TGF-beta signaling. Able to autophosphorylate on Tyr residue; it is however unclear whether it has tyrosine-protein kinase toward other proteins.

Mainly autophosphorylated on serine/threonine residues. Also autophosphorylated on Tyr-198.

It is uncertain whether palmitoylation is on Cys-6 and/or Cys-8.

Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.

Ubiquitously expressed at very low levels.

• Cytoplasm
• Perinuclear region
• Membrane
• Lipid-anchor
• Associates with Golgi and Golgi-derived vesicles.

MPSK1, PKL12, TSF1, STK16, Serine/threonine-protein kinase 16, Myristoylated and palmitoylated serine/threonine-protein kinase, Protein kinase PKL12, TGF-beta-stimulated factor 1, Tyrosine-protein kinase STK16, hPSK, MPSK, TSF-1

• entrezGene:8576
• omim:604719
• swissprot:O75716

Proteins

34656Da