STK25

Oxidant stress-activated serine/threonine kinase that may play a role in the response to environmental stress. Targets to the Golgi apparatus where it appears to regulate protein transport events, cell adhesion, and polarity complexes important for cell migration. Part of the striatin-interacting phosphatase and kinase (STRIPAK) complexes. STRIPAK complexes have critical roles in protein (de)phosphorylation and are regulators of multiple signaling pathways including Hippo, MAPK, nuclear receptor and cytoskeleton remodeling. Different types of STRIPAK complexes are involved in a variety of biological processes such as cell growth, differentiation, apoptosis, metabolism and immune regulation (PubMed:18782753).

Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.

Ubiquitously expressed. Highest levels are found in testis, large intestine, brain and stomach followed by heart and lung.

• Cytoplasm
• Golgi apparatus
• Localizes to the Golgi apparatus.

SOK1, YSK1, STK25, Serine/threonine-protein kinase 25, Ste20-like kinase, Sterile 20/oxidant stress-response kinase 1, SOK-1, Ste20/oxidant stress response kinase 1

• entrezGene:10494
• omim:602255
• swissprot:O00506

Proteins

Oncology

48112Da