STK38
Domain
The UFM1-interacting motif (UFIM) specifically recognizes and binds ufmylated histone H4.
Function
Serine/threonine-protein kinase that acts as a negative regulator of MAP3K1/2 signaling (PubMed:12493777, PubMed:15197186, PubMed:17906693, PubMed:7761441). Converts MAP3K2 from its phosphorylated form to its non-phosphorylated form and inhibits autophosphorylation of MAP3K2 (PubMed:12493777, PubMed:15197186, PubMed:17906693, PubMed:7761441). Acts as an ufmylation 'reader' in a kinase-independent manner: specifically recognizes and binds mono-ufmylated histone H4 in response to DNA damage, promoting the recruitment of SUV39H1 to the double-strand breaks, resulting in ATM activation (PubMed:32537488).
Post-translational modifications
ISGylated.
Phosphorylated by STK3/MST2 and this is enhanced by MOBKL1B.
Sequence Similarities
Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.
Tissue Specificity
Ubiquitously expressed with highest levels observed in peripheral blood leukocytes.
Cellular localization
- Nucleus
- Cytoplasm
- Chromosome
- Localizes to DNA double-strand breaks in response to DNA damage.
Alternative names
NDR1, STK38, Serine/threonine-protein kinase 38, NDR1 protein kinase, Nuclear Dbf2-related kinase 1