STMN3

Function

Exhibits microtubule-destabilizing activity, which is antagonized by STAT3.

Post-translational modifications

N-terminal palmitoylation promotes specific anchoring to the cytosolic leaflet of Golgi membranes and subsequent vesicular trafficking along dendrites and axons. Neuronal Stathmins are substrates for palmitoyltransferases ZDHHC3, ZDHHC7 and ZDHHC15.

Sequence similarities

Belongs to the stathmin family.

Tissue specificity

Neuron specific.

Cellular localization

• Golgi apparatus
• Cell projection
• Growth cone
• Cell projection
• Axon
• Cytoplasm
• Cytosol

Alternative names

• Stathmin-3
• SCG10-like protein
• STMN3
• SCLIP

Database links

• entrezGene:50861
• omim:608362
• swissprot:Q9NZ72

Target type

Proteins

Molecular weight

21017Da