STOML1
Function
May play a role in cholesterol transfer to late endosomes (PubMed:19696025). May play a role in modulating membrane acid-sensing ion channels. Can specifically inhibit proton-gated current of ASIC1 isoform 1. Can increase inactivation speed of ASIC3. May be involved in regulation of proton sensing in dorsal root ganglions (By similarity). May play a role in protecting FBXW7 isoform 3 from degradation (PubMed:23082202).
Sequence Similarities
Belongs to the band 7/mec-2 family.
Tissue Specificity
Ubiquitously expressed at low levels. Expression is highest in brain.
Cellular localization
- Membrane
- Single-pass type III membrane protein
- Late endosome membrane
- Membrane raft
- Cell membrane
- Single-pass type III membrane protein
- Cytoplasmic vesicle
Alternative names
SLP1, UNC24, MSTP019, STOML1, Stomatin-like protein 1, SLP-1, EPB72-like protein 1, Protein unc-24 homolog, Stomatin-related protein, STORP