STRA8
Developmental stage
Expression detected in fetal ovaries between wpf (weeks post-fertilization) 11 and 27; expression peaks at wpf 14.5 and is decreasing afterwards.
Function
Meiosis-inducer required for the transition into meiosis for both female and male germ cells. In female germ cells, acts downstream of ZGLP1 as a key effector of the meiotic program: required for premeiotic DNA replication and subsequent events in meiotic prophase. During spermatogenesis, next to its role in meiotic initiation, promotes (but is not required for) spermatogonial differentiation. In complex with MEIOSIN, directly activates the transcription of a subset of critical meiotic genes playing a central role in cell-cycle switching from mitosis to meiosis.
Post-translational modifications
Phosphorylated.
Tissue Specificity
Expressed specifically in testis and fetal ovaries.
Cellular localization
- Cytoplasm
- Nucleus
- Shuttles between nucleus and cytoplasm. Nuclear export is XPO1-dependent.
Alternative names
Stimulated by retinoic acid gene 8 protein homolog, STRA8