Streptolysin O

A cholesterol-dependent toxin that causes cytolysis by forming pores in cholesterol containing host membranes. After binding to target membranes, the protein undergoes a major conformation change, leading to its insertion in the host membrane and formation of an oligomeric pore complex. Cholesterol is required for binding to host membranes, membrane insertion and pore formation; cholesterol binding is mediated by a Thr-Leu pair in the C-terminus. Can be reversibly inactivated by oxidation.

Belongs to the cholesterol-dependent cytolysin family.

• Secreted
• Host cell membrane
• Multi-pass membrane protein
• Probably secreted as soluble protein by the accessory Sec system (By similarity). It then inserts into the host cell membrane and forms pores formed by transmembrane beta-strands (By similarity).

Streptolysin O, SLO, Thiol-activated cytolysin, slo

• swissprot:Q54114

Proteins

Neuroscience

63992Da