Striatin
Function
Calmodulin-binding scaffolding protein which is the center of the striatin-interacting phosphatase and kinase (STRIPAK) complexes (PubMed:18782753). STRIPAK complexes have critical roles in protein (de)phosphorylation and are regulators of multiple signaling pathways including Hippo, MAPK, nuclear receptor and cytoskeleton remodeling. Different types of STRIPAK complexes are involved in a variety of biological processes such as cell growth, differentiation, apoptosis, metabolism and immune regulation (Probable).
Sequence Similarities
Belongs to the WD repeat striatin family.
Tissue Specificity
Preferentially expressed in brain.
Cellular localization
- Cytoplasm
- Membrane
- Peripheral membrane protein
- Cell projection
- Dendritic spine
- CTTNBP2-binding may regulate dendritic spine distribution.
Alternative names
Striatin, STRN