STX8
Function
Vesicle trafficking protein that functions in the early secretory pathway, possibly by mediating retrograde transport from cis-Golgi membranes to the ER.
Post-translational modifications
Ubiquitinated by HECTD3.
Sequence Similarities
Belongs to the syntaxin family.
Tissue Specificity
Highly expressed in heart. Also found in brain, kidney, liver, lung, placenta, skeletal muscle, spleen and pancreas.
Cellular localization
- Membrane
- Single-pass type IV membrane protein
- Preferentially associated with the early endosome. To a lesser extent, also present in late endosome, the plasma membrane and coated pits (By similarity).
Alternative names
Syntaxin-8, STX8