stxA
Function
The A subunit is responsible for inhibiting protein synthesis through the catalytic inactivation of 60S ribosomal subunits. After endocytosis, the A subunit is cleaved by furin in two fragments, A1 and A2: A1 is the catalytically active fragment, and A2 is essential for holotoxin assembly with the B subunits.
Sequence Similarities
Belongs to the ribosome-inactivating protein family.
Cellular localization
- Secreted
Alternative names
sltA, stxA, Shiga-like toxin 1 subunit A, SLT-1 A subunit, SLT-1a, SLT-Ia, Verocytotoxin 1 subunit A, Verotoxin 1 subunit A, rRNA N-glycosidase 1