STYK1
Function
Probable tyrosine protein-kinase, which has strong transforming capabilities on a variety of cell lines. When overexpressed, it can also induce tumor cell invasion as well as metastasis in distant organs. May act by activating both MAP kinase and phosphatidylinositol 3'-kinases (PI3K) pathways (By similarity).
Sequence Similarities
Belongs to the protein kinase superfamily. Tyr protein kinase family.
Tissue Specificity
Widely expressed. Highly expressed in brain, placenta and prostate. Expressed in tumor cells such as hepatoma cells L-02, cervix carcinoma cells HeLa, ovary cancer cells Ho8910 and chronic myelogenous leukemia cells K-562, but not in other tumor cells such as epidermoid carcinoma (A-431). Undetectable in most normal lung tissues, widely expressed in lung cancers.
Cellular localization
- Membrane
- Single-pass membrane protein
Alternative names
NOK, STYK1, Tyrosine-protein kinase STYK1, Novel oncogene with kinase domain, Protein PK-unique, Serine/threonine/tyrosine kinase 1