SUDS3
Domain
The C-terminus is involved in transcriptional repression by HDAC-independent mechanisms.
Function
Regulatory protein which represses transcription and augments histone deacetylase activity of HDAC1. May have a potential role in tumor suppressor pathways through regulation of apoptosis. May function in the assembly and/or enzymatic activity of the mSin3A corepressor complex or in mediating interactions between the complex and other regulatory complexes.
Post-translational modifications
Polyubiquitinated. 'Lys-63'-polyubiquitinated SUDS3 positively regulates histone deacetylation. Regulated through deubiquitination by USP17L2/USP17 that cleaves 'Lys-63'-linked ubiquitin chains.
Sequence Similarities
Belongs to the SDS3 family.
Tissue Specificity
Expressed in various cancer cell ines.
Cellular localization
- Nucleus
Alternative names
SAP45, SDS3, SUDS3, Sin3 histone deacetylase corepressor complex component SDS3, 45 kDa Sin3-associated polypeptide, Suppressor of defective silencing 3 protein homolog