SUGT1
Domain
The CS domain mediates interaction with HSP90.
Function
May play a role in ubiquitination and subsequent proteasomal degradation of target proteins.
Post-translational modifications
Phosphorylated at Ser-281 and Ser-331, dephosphorylation promotes nuclear translocation, most likely due to disruption of the SUGT1-HSP90 complex.
Sequence Similarities
Belongs to the SGT1 family.
Cellular localization
- Cytoplasm
- Nucleus
- Translocates to the nucleus upon heat shock, requiring S100A6.
Alternative names
Protein SGT1 homolog, Protein 40-6-3, Sgt1, Suppressor of G2 allele of SKP1 homolog, SUGT1