SUGT1

The CS domain mediates interaction with HSP90.

May play a role in ubiquitination and subsequent proteasomal degradation of target proteins.

Phosphorylated at Ser-281 and Ser-331, dephosphorylation promotes nuclear translocation, most likely due to disruption of the SUGT1-HSP90 complex.

Belongs to the SGT1 family.

• Cytoplasm
• Nucleus
• Translocates to the nucleus upon heat shock, requiring S100A6.

Protein SGT1 homolog, Protein 40-6-3, Sgt1, Suppressor of G2 allele of SKP1 homolog, SUGT1

• entrezGene:10910
• omim:604098
• swissprot:Q9Y2Z0

Proteins

41024Da