SULF2
Function
Exhibits arylsulfatase activity and highly specific endoglucosamine-6-sulfatase activity (PubMed:12368295, PubMed:30788513, PubMed:35294879). It can remove sulfate from the C-6 position of glucosamine within specific subregions of intact heparin (PubMed:12368295, PubMed:30788513, PubMed:35294879).
Post-translational modifications
Processing by furin produces a secreted form.
Glycosylation at Ser-583 negatively regulates its N-acetylglucosamine-6-sulfatase and arylsulfatase activities.
The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity.
Sequence Similarities
Belongs to the sulfatase family.
Tissue Specificity
Expressed at highest levels in the ovary, skeletal muscle, stomach, brain, uterus, heart, kidney and placenta.
Cellular localization
- Endoplasmic reticulum
- Golgi apparatus
- Golgi stack
- Cell surface
- Extracellular sulfatase Sulf-2 secreted form
- Secreted
Alternative names
KIAA1247, UNQ559/PRO1120, SULF2, Extracellular sulfatase Sulf-2, hSulf-2, Arylsulfatase, N-acetylglucosamine-6-sulfatase