SULT1C2
Function
Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of phenolic compounds. Does not sulfonate steroids, dopamine, acetaminophen, or alpha-naphthol (PubMed:10481272, PubMed:10783263, PubMed:9852044). Catalyzes the sulfonation of the carcinogenic N-Hydroxy-2-acetylaminofluorene leading to highly reactive intermediates capable of forming DNA adducts, potentially resulting in mutagenesis (PubMed:9852044).
Sequence Similarities
Belongs to the sulfotransferase 1 family.
Tissue Specificity
Found in adult stomach, kidney and thyroid gland, and in fetal kidney and liver.
Cellular localization
- Cytoplasm
- Lysosome
Alternative names
SULT1C1, SULT1C2, Sulfotransferase 1C2, ST1C2, Sulfotransferase 1C1, humSULTC2, SULT1C#1