SULT1C2

Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of phenolic compounds. Does not sulfonate steroids, dopamine, acetaminophen, or alpha-naphthol (PubMed:10481272, PubMed:10783263, PubMed:9852044). Catalyzes the sulfonation of the carcinogenic N-Hydroxy-2-acetylaminofluorene leading to highly reactive intermediates capable of forming DNA adducts, potentially resulting in mutagenesis (PubMed:9852044).

Belongs to the sulfotransferase 1 family.

Found in adult stomach, kidney and thyroid gland, and in fetal kidney and liver.

• Cytoplasm
• Lysosome

SULT1C1, SULT1C2, Sulfotransferase 1C2, ST1C2, Sulfotransferase 1C1, humSULTC2, SULT1C#1

• entrezGene:6819
• omim:602385
• swissprot:O00338

Proteins

Metabolism

34880Da