SUMO3

Function

Ubiquitin-like protein which can be covalently attached to target lysines either as a monomer or as a lysine-linked polymer. Does not seem to be involved in protein degradation and may function as an antagonist of ubiquitin in the degradation process. Plays a role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Covalent attachment to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by an E3 ligase such as PIAS1-4, RANBP2 or CBX4 (PubMed:11451954, PubMed:18538659, PubMed:21965678). Plays a role in the regulation of sumoylation status of SETX (PubMed:24105744).

Post-translational modifications

Polymeric chains can be formed through Lys-11 cross-linking.

Cleavage of precursor form by SENP1, SENP2 or SENP5 is necessary for function.

Sequence Similarities

Belongs to the ubiquitin family. SUMO subfamily.

Tissue Specificity

Expressed predominantly in liver.

Cellular localization

• Cytoplasm
• Nucleus
• Nucleus
• PML body

Alternative names

SMT3A, SMT3H1, SUMO3, Small ubiquitin-related modifier 3, SUMO-3, SMT3 homolog 1, SUMO-2, Ubiquitin-like protein SMT3A, Smt3A

Database links

swissprot:P55854 swissprot:P61956 omim:603042 omim:602231 entrezGene:6613 entrezGene:6612