Superoxide dismutase [Mn], mitochondrial

Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems.

Microvascular complications of diabetes 6

MVCD6

Pathological conditions that develop in numerous tissues and organs as a consequence of diabetes mellitus. They include diabetic retinopathy, diabetic nephropathy leading to end-stage renal disease, and diabetic neuropathy. Diabetic retinopathy remains the major cause of new-onset blindness among diabetic adults. It is characterized by vascular permeability and increased tissue ischemia and angiogenesis.

None

Disease susceptibility is associated with variants affecting the gene represented in this entry.

Nitrated under oxidative stress. Nitration coupled with oxidation inhibits the catalytic activity.

Acetylation at Lys-122 decreases enzymatic activity. Deacetylated by SIRT3 upon exposure to ionizing radiations or after long fasting (By similarity).

Polyubiquitinated; leading to proteasomal degradation. Deubiquitinated by USP36 which increases protein stability.

Belongs to the iron/manganese superoxide dismutase family.

• Mitochondrion matrix

SOD2

• entrezGene:6648
• omim:147460
• swissprot:P04179

Proteins

Immuno-oncology

24750Da