Superoxide dismutase [Mn], mitochondrial
GeneName
SOD2
Summary
SOD2, also known as Mn SOD or SOD-2, is a 25 kDa mitochondrial enzyme that plays a crucial role in the detoxification of superoxide radicals by catalysing their conversion into hydrogen peroxide and molecular oxygen. It is primarily located in the mitochondrial matrix and is essential for maintaining cellular redox balance and protecting cells from oxidative stress. SOD2 is involved in various biological processes including the regulation of blood pressure, cellular responses to oxidative stress, and apoptosis. Its function is supported by its ability to bind manganese ions and its superoxide dismutase activity, which is vital for cellular health and function.
Importance
SOD2 is relevant to: - The study of oxidative stress and its implications in ageing and various diseases, including neurodegenerative disorders and cancer. - Research on mitochondrial function and its role in metabolic diseases, given its location and function within mitochondria. - Investigations into cardiovascular health, particularly in the context of blood pressure regulation and vascular function. - Understanding apoptotic pathways, especially in relation to DNA damage and cellular responses to stress.
Top Products
For researchers investigating SOD2, we recommend two excellent primary antibodies. The first is the well-cited polyclonal antibody, Anti-SOD2/MnSOD antibody (ab13533), which has garnered 365 citations, highlighting its reliability in Western blotting (WB). Additionally, we offer the recombinant antibody, Anti-SOD2/MnSOD antibody [EPR2560Y] (ab68155). This product is validated in knockout models and is suitable for both WB and immunohistochemistry (IHC), making it a versatile choice for those requiring consistent performance across different applications. With 113 citations, it is also gaining recognition in the research community. The Anti-SOD2/MnSOD antibody ELISA Kit (ab110300), supported by 11 citations, is an excellent option for researchers looking to accurately measure SOD2 levels in their samples.
Abcam Product Citation Summary
The data indicates a significant focus on the role of SOD2 in various biological contexts, particularly in relation to oxidative stress, mitochondrial function, and cellular responses to different stimuli. Studies involving human and mouse models highlight the importance of SOD2 in conditions such as myocardial infarction, ALS, and cancer, suggesting its potential as a therapeutic target in oxidative stress-related diseases.
Abcam Product Citation Table
Function
Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems.
Involvement in disease
Microvascular complications of diabetes 6
MVCD6
Pathological conditions that develop in numerous tissues and organs as a consequence of diabetes mellitus. They include diabetic retinopathy, diabetic nephropathy leading to end-stage renal disease, and diabetic neuropathy. Diabetic retinopathy remains the major cause of new-onset blindness among diabetic adults. It is characterized by vascular permeability and increased tissue ischemia and angiogenesis.
None
Disease susceptibility is associated with variants affecting the gene represented in this entry.
Post-translational modifications
Nitrated under oxidative stress. Nitration coupled with oxidation inhibits the catalytic activity.
Acetylation at Lys-122 decreases enzymatic activity. Deacetylated by SIRT3 upon exposure to ionizing radiations or after long fasting (By similarity).
Polyubiquitinated; leading to proteasomal degradation. Deubiquitinated by USP36 which increases protein stability.
Sequence Similarities
Belongs to the iron/manganese superoxide dismutase family.
Cellular localization
- Mitochondrion matrix
Alternative names
SOD2