SUPV3L1
Function
Major helicase player in mitochondrial RNA metabolism. Component of the mitochondrial degradosome (mtEXO) complex, that degrades 3' overhang double-stranded RNA with a 3'-to-5' directionality in an ATP-dependent manner. Involved in the degradation of non-coding mitochondrial transcripts (MT-ncRNA) and tRNA-like molecules (PubMed:29967381). ATPase and ATP-dependent multisubstrate helicase, able to unwind double-stranded (ds) DNA and RNA, and RNA/DNA heteroduplexes in the 5'-to-3' direction. Plays a role in the RNA surveillance system in mitochondria; regulates the stability of mature mRNAs, the removal of aberrantly formed mRNAs and the rapid degradation of non coding processing intermediates. Also implicated in recombination and chromatin maintenance pathways. May protect cells from apoptosis. Associates with mitochondrial DNA.
Sequence Similarities
Belongs to the helicase family.
Tissue Specificity
Broadly expressed.
Cellular localization
- Nucleus
- Mitochondrion matrix
- Mitochondrion matrix
- Mitochondrion nucleoid
Alternative names
SUV3, SUPV3L1, Suppressor of var1 3-like protein 1, SUV3-like protein 1