SUSD2

May be a cytokine receptor for GPR15LG. May be a tumor suppressor; together with GPR15LG has a growth inhibitory effect on colon cancer cells which includes G1 cell cycle arrest (PubMed:25351403). May play a role in breast tumorigenesis (PubMed:23131994).

Highly expressed in breast cancer, but shows a restricted expression pattern in normal tissues such as adipose, adrenal gland, kidney, lung, mammary gland, placenta, thyroid, trachea, and uterus (PubMed:23131994). Also expressed in colon; down-regulated in colon cancer tissues (PubMed:25351403).

• Cell membrane
• Single-pass type I membrane protein
• SUSD2 and LGALS1 co-localized in very specific, punctate regions along the cell membrane of breast cancer cells.

Sushi domain-containing protein 2, SUSD2

• entrezGene:56241
• swissprot:Q9UGT4

Proteins

Developmental Biology

90208Da