Sushi repeat-containing protein SRPX2
Function
Acts as a ligand for the urokinase plasminogen activator surface receptor. Plays a role in angiogenesis by inducing endothelial cell migration and the formation of vascular network (cords). Involved in cellular migration and adhesion. Increases the phosphorylation levels of FAK. Interacts with and increases the mitogenic activity of HGF. Promotes synapse formation. Required for ultrasonic vocalizations.
Post-translational modifications
Contains chondroitin sulfate chains.
Tissue Specificity
Expressed in angiogenic endothelial cells (at protein level).
Cellular localization
- Secreted
- Cytoplasm
- Cell surface
- Synapse
Alternative names
Sushi repeat-containing protein SRPX2, Srpx2