SV2A

Function

Plays a role in the control of regulated secretion in neural and endocrine cells, enhancing selectively low-frequency neurotransmission. Positively regulates vesicle fusion by maintaining the readily releasable pool of secretory vesicles (By similarity).

(Microbial infection) Receptor for the C.botulinum neurotoxin type A2 (BoNT/A, botA); glycosylation is not essential but enhances the interaction (PubMed:29649119). Probably also serves as a receptor for the closely related C.botulinum neurotoxin type A1.

Post-translational modifications

Phosphorylation by CK1 of the N-terminal cytoplasmic domain regulates interaction with SYT1.

N-glycosylated.

Sequence similarities

Belongs to the major facilitator superfamily.

Cellular localization

• Cell junction
• Synapse
• Presynapse
• Cytoplasmic vesicle
• Secretory vesicle
• Synaptic vesicle membrane
• Multi-pass membrane protein
• Enriched in chromaffin granules, not present in adrenal microsomes. Associated with both insulin granules and synaptic-like microvesicles in insulin-secreting cells of the pancreas (By similarity). Colocalizes with ATP2B1 at photoreceptor synaptic terminals.

Alternative names

• Synaptic vesicle glycoprotein 2A
• PSEC0174
• SV2A
• KIAA0736

Database links

• entrezGene:9900
• omim:185860
• swissprot:Q7L0J3

Target type

Proteins

Primary research area

Neuroscience

Molecular weight

82695Da